Discovery Biology Laboratory
Greater Boston, USA
The Sai Life Sciences Discovery Biology Laboratory is located in Greater Boston, one of the world’s leading life sciences and biotechnology clusters. The location enables close, real-time collaboration with start-ups, emerging biotechs, and global innovators working at the forefront of drug discovery.
The laboratory provides exploratory biology services for complex and fast-moving research programs, including novel target interrogation, rapid assay development, early validation studies, and iterative hypothesis testing across multiple modalities and disease areas. It operates as part of Sai Life Sciences’ fully integrated global discovery biology platform, combining close collaboration in the US with deep scientific capability, scale, and execution strength in India.
Site Highlights
- Purpose-built for exploratory biology and early discovery
- Advanced cellular, biochemical and biophysical platforms
- Expert scientists driving assay development and target validation
- Integrated with India-based teams for speed and scale
- Flexible environment for complex, evolving programs
- Designed for close scientific collaboration
- Secure infrastructure to protect client IP
Our Services
We offer fit-for-purpose exploratory biology tailored to program needs, spanning early target interrogation through mechanism validation and lead support. Our teams in the US and India work in an integrated manner to ensure continuity from assay development through data generation and interpretation.
Novel assay development (biochemical, cellular, biophysical and phenotypic)
- Co-culture assays
- Whole blood stimulation assays
- Receptor quantification and binding (flow based)
- Primary cell models
Target and biomarker identification and validation
- siRNA, shRNA, ASO, CRISPR
Mechanism of action (MoA) studies and pathway interrogation
- mTOR, NFkB, GPCR target validation
- Orthogonal assay validation
Cell-based assays and high-content screening
- Receptor quantification and internalization
- Neurite outgrowth of iPSC derived neuronal cell types
- Reactive Oxygen Species (ROS) protection assays
- Translocation quantitative assay
- Transfection efficiency quantification
- Phenotypic and functional assays
Cellular target engagement and in vitro biomarker assessment
- NanoBRET cell-based assays
- FRET/TR-FRET assays
- AlphaLISA assays
- Fluorescence Polarization (FP)
- Palmitic acid competition assays
Reagent qualification and assay robustness optimization
- Cell line screen, cell density, kinetics, drug dose optimization
- Agonist and antagonist mode validation
- Antibody screen, titration, and saturation
- LOD and LOQ determination
Biophysics (SPR & MST)
- Affinity screening
- Small molecules, PROTACS, Peptides, Large molecules
- Fragment screening hit identification, confirmation, validation
- Fragment library screening services
Comprehensive fragment screening and hit confirmation
Comprehensive fragment screening and hit confirmation
The Boston Advantage
Proximity & Next-door lab concept within USA for in vitro biology services for rapid turnaround times
• Routine biochemical & biophysical assays: 3 days
• Routine cellular assays: 5 days
• Cell line generation: 4 weeks
• Thorough validation of every assay
• Reproducibility ensured
Boston Team

Maneesh Pingle
Executive Vice President &
Head of Discovery Services

Sonela Cavicke
Head of Discovery
Business Development

Carlos Pedraza
Associate Vice President,
Discovery Services

Ajita Singh
Associate Director
Biology

Gavin Histen
Principal Scientist
Biology
Testimonials
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